abstract：:Genetic alterations occurring in various chromosomes have been described in many human tumors. The DCC gene was originally identified in colorectal cancer and was reported as a tumor suppressor gene that might be related to tumor metastasis. We investigated 10 cell lines and 15 fresh tumors of childhood rhabdomyosarco...

journal_title：International journal of molecular medicine

authors： Choi SH,Kong XT,Taki T,Tsuchida Y,Kawaguchi H,Kato H,Hanada R,Look AT,Hayashi Y

更新日期：2000-10-01 00:00:00

abstract：:Midkine (MK), a retinoic acid responsible protein, is regulated during development and may play an important role in tumorigenesis. A search for genetic variations of the MK gene, located on chromosome 11q11.2 in humans, has not yet been conducted in cancers. To examine the entire coding region, as well as 4 regions o...

journal_title：International journal of molecular medicine

authors： Ahmed KM,Shitara Y,Kuwano H,Takenoshita S,Uchimuro K,Shinozawa T

更新日期：2000-09-01 00:00:00

abstract：:We studied whether feeding pregnant female mice with different fats affects lipid exchange and activity of the splenic lymphoid system in offspring exposed to low doses of carcinogen. Female mice were fed diets with either 7% or 15% corn oil or olive oil. The 4-week-old offspring of these mice were transferred to a ch...

journal_title：International journal of molecular medicine

authors： Zusman I,Ben-Hur H,Budovsky A,Geva D,Gurevich P,Tendler Y,Lavee S,Stark A,Madar Z

更新日期：2000-09-01 00:00:00

abstract：:Hepatoblastoma is a rare pediatric liver tumor. While much progress has been made in the treatment of the disease, very little is known about the moleculer events underlying the pathogenesis of this disease. We sought to investigate a series of hepatoblastomas for alterations in gene expression patterns with emphasis ...

journal_title：International journal of molecular medicine

authors： Gray SG,Hartmann W,Eriksson T,Ekstrom C,Holm S,Kytola S,von Schweinitz D,Pietsch T,Larsson C,Kogner P,Sandstedt B,Ekstrom TJ

更新日期：2000-08-01 00:00:00

abstract：:It is now well established that immune effector mechanisms contribute to cardiac dysfunction in several heart diseases, including myocarditis and the associated dilated cardiomyopathy, heart transplant rejection and Chagas' disease. These and other pathologies, in which cellular immunity plays an important role, contr...

journal_title：International journal of molecular medicine

authors： Binah O

更新日期：2000-07-01 00:00:00

abstract：:Peroxisome proliferator activated receptors (PPARs) are nuclear receptors regulating the expression of genes involved in lipid and glucose metabolism. Three different PPARs; alpha (PPARA), gamma (PPARG) and delta (PPARD) have been characterized and they are distinguished from each other by tissue distribution and cell...

journal_title：International journal of molecular medicine

authors： Skogsberg J,Kannisto K,Roshani L,Gagne E,Hamsten A,Larsson C,Ehrenborg E

更新日期：2000-07-01 00:00:00

abstract：:Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominantly inherited cancer syndrome (OMIM 131100), with tumours in several endocrine glands. In 1997 the responsible tumour suppressor gene was identified and recently it was shown that menin, its encoded protein, represses JunD-activated gene expression. Al...

journal_title：International journal of molecular medicine

authors： Roijers JF,Apel T,Neumann HP,Arnim UV,Lips CJ,Hoppener JW

更新日期：2000-06-01 00:00:00

abstract：:Angiogenesis is an important process in several physiological situations and it is also implicated in the development of some diseases such as diabetes and cancer. This study investigated the antiangiogenic potential of Chrysobalanus icaco methanol extract in the chicken embrionary tissue. Clinical trials for cancer t...

journal_title：International journal of molecular medicine

authors： Alves De Paulo S,Teruszkin Balassiano I,Henriques Silva N,Oliveira Castilho R,Coelho Kaplan MA,Currie Cabral M,da Costa Carvalho MG

更新日期：2000-06-01 00:00:00

abstract：:Bloom syndrome (BS) is a rare genetic disorder characterized by small body size, photosensitivity, immunodeficiency and a high predisposition to various types of cancer. BLM was identified as the causative gene for BS. The BLM protein is homologous to DNA helicase and has two basic amino acid clusters in its C-termina...

journal_title：International journal of molecular medicine

authors： Hayakawa S,Kaneko H,Fukao T,Kasahara K,Matsumoto T,Furuichi Y,Kondo N

更新日期：2000-05-01 00:00:00

abstract：:Previously, a specific angiogenesis inhibitor, angiostatin, discovered in urine and serum of tumor-bearing mice, was reported to potently block tumor growth and metastasis in animal models. Detection of angiostatin and its precursor proteins in urine from cancer patients has not been reported. Now, we report the devel...

journal_title：International journal of molecular medicine

authors： Cao Y,Veitonmaki N,Keough K,Cheng H,Lee LS,Zurakowski D

更新日期：2000-05-01 00:00:00

abstract：:We evaluated the postoperative adjuvant chemotherapy by UFT using the primary tumor amputation-pulmonary metastasis model. When Lewis lung carcinoma (LLC) primary tumors on the hind foot pad grew palpable, they were amputated on two different days. In experiment (A) (earlier amputation model), micrometastases were det...

journal_title：International journal of molecular medicine

authors： Uchida J,Sato K,Okabe H,Saito H,Nakano K,Fujioka A,Takechi T,Takeda S,Unemi N,Fukushima M

更新日期：2000-04-01 00:00:00

abstract：:The complement system participates in the local immune system of the lung. In this study, we investigated the secretion of complement components of the alternative pathway (C3 and factor B) in the alveolar type II epithelial cell line A549. The levels of C3 and factor B protein in the culture medium were determined by...

journal_title：International journal of molecular medicine

authors： Zhao YX,Andoh A,Shimada M,Takaya H,Hata K,Fujiyama Y,Bamda T

更新日期：2000-04-01 00:00:00

abstract：:Estrogen receptors (ER) are present in various reproductive tissues as well as in other tissues not considered classical targets for estrogen. A variety of alternatively spliced ER variants which co-exist with the wild-type receptor has also been described in many tissues. We analyzed the presence of both wild-type an...

journal_title：International journal of molecular medicine

authors： Yang J,Liu A,Chiou SK,Guzman R,Nandi S

更新日期：2000-03-01 00:00:00

abstract：:Regucalcin is a Ca2+-binding protein which plays a regulatory role in liver cell functions related to Ca2+. In this study we have cloned and characterized cDNA for regucalcin from human liver and human hepatoma cell line Hep G2 by screening and rapid amplification of cDNA ends (RACE). The nucleotide sequences of the c...

journal_title：International journal of molecular medicine

authors： Misawa H,Yamaguchi M

更新日期：2000-03-01 00:00:00

abstract：:The expression of thymidylate synthase (TS) in human cancer tissues has been suggested to be a prognostic factor for patients receiving 5-fluorouracil-based chemotherapy. We generated monoclonal antibodies to both recombinant and native TS and analyzed the epitopes on the TS molecule. Two monoclonal antibodies were ob...

journal_title：International journal of molecular medicine

authors： Okabe H,Koizumi K,Tsujimoto H,Fukushima M

更新日期：2000-02-01 00:00:00

abstract：:Carcinoma of the head and neck is the sixth leading cause of cancer in the world, and the third most common neoplasia in developing countries. More than 90% of head and neck cancers are squamous cell carcinomas (SCCHN). Approximately half of the patients afflicted die within 5 years of diagnosis and survival rates for...

journal_title：International journal of molecular medicine

authors： McLaughlin PJ,Levin RJ,Zagon IS

更新日期：2000-02-01 00:00:00

abstract：:Members of the basic helix-loop-helix (bHLH) family of transcription factors have been implicated in the regulation of cell proliferation and differentiation. Here we describe molecular characterization of mesoderm-specific bHLH protein, POD-1/Capsulin. Northern blot analysis showed that POD-1/Capsulin are preferentia...

journal_title：International journal of molecular medicine

authors： Miyagishi M,Nakajima T,Fukamizu A

更新日期：2000-01-01 00:00:00

abstract：:The relationship between cell proliferation, protein tyrosine phosphorylation, phosphotyrosine kinase activity and bradykinin receptor activation in rat mesangial cells was investigated. We demonstrated that bradykinin (BK), through the B2 receptor, induced a dose-dependent inhibition of mesangial cell proliferation s...

journal_title：International journal of molecular medicine

authors： Alric C,Pecher C,Schanstra JP,Bascands JL,Girolami JP

更新日期：2000-01-01 00:00:00

abstract：:Clinical situations with release of proteinases from blood cells or tissues into the circulation may result in a marked decrease of blood proteinase inhibitor content which in turn may result in a capillary leak syndrome, shock and even in exitus letalis. Replenishment of blood proteinase inhibitors is of benefit in s...

journal_title：International journal of molecular medicine

authors： Langner J,Thiem M,Bohning V

更新日期：1999-12-01 00:00:00

abstract：:The effect of interferon-alpha (IFN) for chronic myeloid leukemia (CML) in the chronic phase (CP) was retrospectively evaluated in comparison with that of busulfan (BU) or hydroxyurea (HU) given alone. Among 107 patients diagnosed with CML between 1982 and 1997, 72 CP cases evaluable for long-term follow-up included 1...

journal_title：International journal of molecular medicine

authors： Itoh T,Tamura S,Takemoto Y,Kakishita E

更新日期：1999-12-01 00:00:00

abstract：:p107 protein, a member of the retinoblastoma family protein, suppresses growth promotion in cancer cells. We have already reported evidence that calpain, a calcium dependent protease is involved in the cleavage of p107 protein. We show here that p107 protein can also be a substrate for ubiquitination. A negative growt...

journal_title：International journal of molecular medicine

authors： Jang JS,Choi YH

更新日期：1999-11-01 00:00:00

abstract：:DNA vaccines raise immune responses by expressing proteins in vaccinated hosts. Responses are raised by nanogram levels of protein expression. Popular methods of DNA delivery include intramuscular (i. m.) injections of DNA in saline and gene gun delivery of DNA-coated gold beads to the epidermis. Professional antigen-...

journal_title：International journal of molecular medicine

authors： Robinson HL

更新日期：1999-11-01 00:00:00

abstract：:Recently a candidate gene for hereditary hemo-chromatosis, HFE, was identified. The finding raises the possibility for genetic testing to provide earlier detection and more complete genotypic evaluation of hemochromatosis affected individuals. We determined the frequency of the HFE polymorphisms, C282Y and H63D, in a ...

journal_title：International journal of molecular medicine

authors： Marshall DS,Linfert DR,Tsongalis GJ

更新日期：1999-10-01 00:00:00

abstract：:Reactive oxygen species (ROS), generated either extracellularly or intracellularly through ligand-receptor interactions, can function as signal transduction molecules to activate the chemotactic cytokine interleukin-8 (IL-8) and the cell surface adhesion protein, intercellular adhesion molecule-1 (ICAM-1; CD54). Toget...

journal_title：International journal of molecular medicine

authors： Roebuck KA

更新日期：1999-09-01 00:00:00

abstract：:Nail-Patella syndrome, or osteo-onychodysplasia, is an autosomal dominant disorder characterized by nail dysplasia, absent or hypoplastic patellae, iliac horns and nephropathy. Previous studies have demonstrated linkage of the Nail-Patella locus with polymorphic markers on human chromosome 9q34. Recently, point mutati...

journal_title：International journal of molecular medicine

authors： Seri M,Melchionda S,Dreyer S,Marini M,Carella M,Cusano R,Piemontese MR,Caroli F,Silengo M,Zelante L,Romeo G,Ravazzolo R,Gasparini P,Lee B

更新日期：1999-09-01 00:00:00

abstract：:We evaluated the mechanism of antitumor effects of buserelin, which is one of LH-RH agonists, on a hormone dependent breast cancer model, using 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary cancer. Rats developing solid mammary tumors within 5-7 weeks following the DMBA administration were divided into gro...

journal_title：International journal of molecular medicine

authors： Koibuchi Y,Sugamata N,Iino Y,Yokoe T,Andoh T,Maemura M,Takei H,Horiguchi J,Matsumoto H,Morishita Y

更新日期：1999-08-01 00:00:00

abstract：:For tumor progression, a cascade of linked sequential biological events is essential. We tried to test whether biological therapy can modulate specific biological phenotypes and increase the anti-tumor effect when combined with chemotherapy. Five human gastric cancer cell lines (YCC-1, YCC-2, YCC-3, YCC-7, AGS) were u...

journal_title：International journal of molecular medicine

authors： Rha SY,Noh SH,Kim TS,Yoo NC,Roh JK,Min JS,Kim BS

更新日期：1999-08-01 00:00:00

abstract：:Three human pleural malignant mesothelioma cell cultures (MM) of epithelioid (E1), fibrous (F1) and byphasic (B1) histotype were studied in their synthesis of the extracellular matrix (ECM) components laminin (LM), fibronectin (FN), type IV collagen (cIV), and in their chemotactic and haptotactic migration towards the...

journal_title：International journal of molecular medicine

authors： Scarpa S,Giuffrida A,Fazi M,Coletti A,Palumbo C,Pass HI,Procopio A,Modesti A

更新日期：1999-07-01 00:00:00

abstract：:Receptor-mediated gene delivery is an attractive method for gene transfer in vitro and shows promise for in vivo gene therapy applications. In the current study, we have selected the cytokine interleukin-2 (IL-2) gene to explore the feasibility of receptor-mediated gene transfer into human hepatocellular carcinoma Hep...

journal_title：International journal of molecular medicine

authors： Junbo H,Li Q,Zaide W,Yunde H

更新日期：1999-06-01 00:00:00

abstract：:Tumor suppressor gene mutations in TSG101, FHIT, and PTEN/MMAC1 were found in many types of cancer and the defects in these genes are responsible for the tumor development. Since aberrant transcripts of these genes were also identified in normal tissues, the significance of these mutations in carcinogenesis has become...

journal_title：International journal of molecular medicine

authors： Wang NM,Chang JG

更新日期：1999-05-01 00:00:00

abstract：:To examine the relationship between pathophysiological effects and molecular features of anti-double-stranded (ds)DNA autoantibodies (Abs), we isolated anti-dsDNA Ab fragments by using the phage-display method. Fd ç and light-chain DNA were PCR amplified from peripheral blood lymphocytes of a patient with systemic lup...

journal_title：International journal of molecular medicine

authors： Suzuki M,Katsube Y,Suzuki H,Takemura H,Sumida T

更新日期：1999-04-01 00:00:00

abstract：:Our earlier reports indicated that the changes of age-adjusted incidence rates (AAIRs) of any 2 tumors in time and space, as investigated by the sequential regression analysis, showed a good fitness to the equilibrium model under the control of the law of mass action. The purpose of this study is to investigate the pr...

journal_title：International journal of molecular medicine

authors： Kodama M,Murakami M,Kodama T

更新日期：1999-04-01 00:00:00

abstract：:Differential diagnosis between adrenal cortical and adrenal medullary lesions may be difficult in many cases. Different immunohistochemical, histochemical tools as well as ultrastructural diagnostic techniques have been employed to aid in differentiating between these lesions. Recently, both inhibin-A and BCL-2 have b...

journal_title：International journal of molecular medicine

authors： Fogt F,Zimmerman RL,Mulligan N,Vortmeyer AO,Poremba C,Harris CA,Alsaigh N,Tomaszewski JE,Nikulasson ST

更新日期：1999-03-01 00:00:00

abstract：:Biochemical modification of extracellular matrix (ECM) proteins can alter the function in overlying cells. We tested the hypothesis that metal-catalyzed oxidation of native ECM and individual matrix proteins modulates the activity of inducible nitric oxide synthase (iNOS) in cultured rat mesangial cells (RMC). Oxidize...

journal_title：International journal of molecular medicine

authors： Trachtman H,Futterweit S,Koss E,Bogart M,Mermelstein A

更新日期：1999-03-01 00:00:00

abstract：:The existence of at least two distinct alpha 1,2fucosyltransferases has been postulated for many years, and recently confirmed in humans with the cloning of the human and rabbit secretor type alpha 1,2fucosyltransferase. We now describe the cloning and analysis of PFUT2, the pig secretor type alpha 1,2fucosyltransfera...

journal_title：International journal of molecular medicine

authors： Cohney S,Mouhtouris E,McKenzie IF,Sandrin MS

更新日期：1999-02-01 00:00:00

abstract：:Clinical trials have started to implement tumor-associated antigens in the form of antigenic peptides in order to augment CD8(+) T-cell responses directed against autologous cancer cells. One of the surrogate markers for successful immunization is the characterization of T-lymphocytes reacting to the immunizing peptid...

journal_title：International journal of molecular medicine

authors： Höhn H,Reichert T,Neukirch C,Pilch H,Maeurer MJ

更新日期：1999-02-01 00:00:00

abstract：:Current therapy for glioma is suboptimal. The transfer of apoptosis genes to tumors constitutes one of the most promising strategies for cancer gene therapy. We have previously shown that massive apoptosis occurs when wild-type p53 or E2F-1 expression is induced in glioma. However, the mechanism of action and the effi...

journal_title：International journal of molecular medicine

authors： Gomez-Manzano C,Fueyo J,Alameda F,Kyritsis AP,Yung WK

更新日期：1999-01-01 00:00:00

abstract：:Electrical activity of beta-cells and cytosolic Ca2+ concentration ([Ca2+]i) were monitored in mouse pancreatic islets exposed to the pentaacetate esters of alpha-D-glucose, beta-D-galactose and beta-L-glucose, all tested at 1.7 mM concentration. In the presence of 5 mM D-glucose, alpha-D-glucose pentaacetate induced ...

journal_title：International journal of molecular medicine

authors： Pomares R,Ropero AB,Sánchez-Andrés JV,Nadal A,Soria B,Malaisse WJ

更新日期：1999-01-01 00:00:00

abstract：:The purpose of this study is to extract common features of an environmental hormone-oriented neoplasia by comparatively investigating the epidemiological characteristics of testicular cancer in Denmark with those of other cancers, of which the age-adjusted incidence rates (AAIRs) underwent remarkable increase or decre...

journal_title：International journal of molecular medicine

authors： Kodama M,Kodama T

更新日期：1998-12-01 00:00:00

abstract：:The membrane cytoskeletal component dystrophin and its associated glycoproteins play a central role in the molecular pathogenesis of several muscular dystrophies, i.e. Duchenne/Becker muscular dystrophy, congenital muscular dystrophy and various forms of limb-girdle muscular dystrophy. Although the most frequent of th...

journal_title：International journal of molecular medicine

authors： Culligan KG,Mackey AJ,Finn DM,Maguire PB,Ohlendieck K

更新日期：1998-12-01 00:00:00